PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 210
... tissue as well as local proliferation of cells and connective tissue . The principal cell types found in areas of chronic inflammation are mononuclear cells and abnormal cells derived from macrophages . In areas of healing and chronic ...
... tissue as well as local proliferation of cells and connective tissue . The principal cell types found in areas of chronic inflammation are mononuclear cells and abnormal cells derived from macrophages . In areas of healing and chronic ...
Pagina 312
... tissue factor ' , which is the cellular receptor and cofactor for factor VII , which undergoes an active site transition on binding to tissue factor in the presence of calcium ions , enhancing its activity and resulting in rapid ...
... tissue factor ' , which is the cellular receptor and cofactor for factor VII , which undergoes an active site transition on binding to tissue factor in the presence of calcium ions , enhancing its activity and resulting in rapid ...
Pagina 666
... tissue - making space for new blood vessels ( see Harris 1997 ) . DEDIFFERENTIATION AND LOSS OF FUNCTION The multiplication of normal cells involves division of the stem cells in a particular tissue to give rise to daughter cells ...
... tissue - making space for new blood vessels ( see Harris 1997 ) . DEDIFFERENTIATION AND LOSS OF FUNCTION The multiplication of normal cells involves division of the stem cells in a particular tissue to give rise to daughter cells ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular