PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 65
... transport Many cell membranes possess specialised transport mechanisms that regulate entry and exit of physio- logically important molecules , such as sugars , amino acids , neurotransmitters and metal ions . Generally , such transport ...
... transport Many cell membranes possess specialised transport mechanisms that regulate entry and exit of physio- logically important molecules , such as sugars , amino acids , neurotransmitters and metal ions . Generally , such transport ...
Pagina 108
... transport process ( Brew & Attwell 1988 ) . Very similar mecha- nisms are responsible for other physiological transport processes , such as glucose uptake ( Ch . 22 ) and renal tubular transport of amino acids . Since it is the electro ...
... transport process ( Brew & Attwell 1988 ) . Very similar mecha- nisms are responsible for other physiological transport processes , such as glucose uptake ( Ch . 22 ) and renal tubular transport of amino acids . Since it is the electro ...
Pagina 354
... transport processes in the proximal convoluted tubule . The main driving force for the absorption of solutes and water from the lumen is the Na + / K + -ATPase in the basolateral membrane of the tubule cells . Many drugs are secreted ...
... transport processes in the proximal convoluted tubule . The main driving force for the absorption of solutes and water from the lumen is the Na + / K + -ATPase in the basolateral membrane of the tubule cells . Many drugs are secreted ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular