PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 168
... types , 5 - HT1-79 of which types 1 and 2 are further subdivided into 3 or 4 sub - categories , denoted A - D . 5 - HT - receptors occur mainly in the brain , the sub- types being distinguished on the basis of their regional ...
... types , 5 - HT1-79 of which types 1 and 2 are further subdivided into 3 or 4 sub - categories , denoted A - D . 5 - HT - receptors occur mainly in the brain , the sub- types being distinguished on the basis of their regional ...
Pagina 210
... types of hypersensitivity , being the initiating factor in Types I , II and III and being involved in both the initiation and effector phase in Type IV . The hypersensitivity reactions given above are the basis of the clinically ...
... types of hypersensitivity , being the initiating factor in Types I , II and III and being involved in both the initiation and effector phase in Type IV . The hypersensitivity reactions given above are the basis of the clinically ...
Pagina 555
... Type A MAO correlates with antidepressant activity . Selective Type A MAOI have recently been introduced . Atypical antidepressants act by various mechanisms , often poorly understood . • All types of antidepressant drug take at least 2 ...
... Type A MAO correlates with antidepressant activity . Selective Type A MAOI have recently been introduced . Atypical antidepressants act by various mechanisms , often poorly understood . • All types of antidepressant drug take at least 2 ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular