PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 99
Pagina 149
... vascular smooth muscle , particularly in the skin and splanchnic vascular beds , which are strongly constricted . Large arteries and veins , as well as arterioles , are also con- stricted , resulting in decreased vascular compliance ...
... vascular smooth muscle , particularly in the skin and splanchnic vascular beds , which are strongly constricted . Large arteries and veins , as well as arterioles , are also con- stricted , resulting in decreased vascular compliance ...
Pagina 278
... vascular smooth muscle tone 279 Regulation of [ Ca2 + ] 279 The role of the vascular endothelium 281 The role of the renin - angiotensin system 283 Drugs that affect vascular smooth muscle contraction 286 Vasoconstrictor drugs 286 ...
... vascular smooth muscle tone 279 Regulation of [ Ca2 + ] 279 The role of the vascular endothelium 281 The role of the renin - angiotensin system 283 Drugs that affect vascular smooth muscle contraction 286 Vasoconstrictor drugs 286 ...
Pagina 279
... vascular system can be broken down into effects on : total peripheral resistance ( controlled mainly by the arterioles ) , which is one of the main determinants of arterial pressure ... VASCULAR SYSTEM Control of vascular smooth muscle tone.
... vascular system can be broken down into effects on : total peripheral resistance ( controlled mainly by the arterioles ) , which is one of the main determinants of arterial pressure ... VASCULAR SYSTEM Control of vascular smooth muscle tone.
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular