Neuroimmunoendocrinology

Copertina anteriore
J. Edwin Blalock
Karger Medical and Scientific Publishers, 1 gen 1997 - 227 pagine
The explosion of information on immuneneuroendocrine interactions has continued unabated since the first and second editions of this volume appeared in 1988 and 1992. This third revised and enlarged edition offers an authoritative update on the latest advances in knowledge of the molecular, structural, and cellular bases of bidirectional communication between the immune and neuroendocrine systems. The eight invited chapters review current evidence that the immune system produces and responds to neuroendocrine peptide hormones and neurotransmitters; that the nervous system produces and responds to cytokines; that the immune system can regulate the neuroendocrine system and vice versa; that the immune system is innervated, and that the neuroendocrine and immune systems share a set of hormone and cytokine receptors. All chapters and bibliographies from the second edition have been expanded to include the most recent literature in these areas. In addition, the text provides a new chapter which is the first to compare the three-dimensional structures of cytokines and hormones complexed with their receptors. As the only text to provide an up-to-the-minute account of the cellular, molecular and structural mechanisms of communication between the immune and neuroendocrine systems, this well-written volume will be of interest to many scientists in the fields of immunology, endocrinology, physiology, neuroscience and structural biology, and will also be a valuable resource for clinicians.
 

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Indice

Regulation of LeukocyteDerived Peptide Hormones
10
Immunologic Cell Types that Produce Peptide Hormones
17
Acknowledgments
23
Oligodendrocytes
37
Expression of Adhesion Molecules
50
Structural Biology of Cytokines Their Receptors
76
Noradrenergic and Peptidergic Innervation of Lymphoid Organs
99
Functional Significance of Innervation
119
References
177
Hormonal Activities of Cytokines E M Smith Galveston Tex 185 Introduction
185
Background
186
New Hormonal Activities
187
IL1 190 IL2 191 IL6 191 IL10 195 Tumor Necrosis Factor 195 Various Cytokines
195
Clinical Studies and Implications
196
Acknowledgments 198 References
198
Interactive Signaling Pathways of the NeuroendocrineImmune Network TL Roszman W H Brooks Lexington Ky 203 Introduction
203

Neuroendocrine Peptide Receptors on Cells of the Immune System
132
InsulinLike Growth Factor Receptor
146
Neuroendocrine Peptide Hormone Regulation of Immunity B A Torres H M Johnson Gainesville Fla 155 Introduction
155
POMC and Proenkephalin Products
156
Arginine Vasopressin
161
ThyroidStimulating Hormone Thyrotropin TSH and Related Hormones
163
Substance
166
Vasoactive Intestinal Peptide
168
Growth Hormone
171
Prolactin
173
Somatostatin
175
Conclusions 176 Acknowledgments
176
Can the Pituitary Gland Modulate the Immune System?
204
Are There Receptors for Neurohormones NH Present on Cells of the Immune System?
206
Can NH Influence the Immune System?
208
How Do NH Modulate TCell Function?
209
Signaling Models
211
NH Modulation of Immune Function Future Directions
216
Conclusions
219
References
220
Author Index
223
Subject Index
224
Copyright

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