NeuroimmunoendocrinologyJ. Edwin Blalock Karger Medical and Scientific Publishers, 1 gen 1997 - 227 pagine The explosion of information on immuneneuroendocrine interactions has continued unabated since the first and second editions of this volume appeared in 1988 and 1992. This third revised and enlarged edition offers an authoritative update on the latest advances in knowledge of the molecular, structural, and cellular bases of bidirectional communication between the immune and neuroendocrine systems. The eight invited chapters review current evidence that the immune system produces and responds to neuroendocrine peptide hormones and neurotransmitters; that the nervous system produces and responds to cytokines; that the immune system can regulate the neuroendocrine system and vice versa; that the immune system is innervated, and that the neuroendocrine and immune systems share a set of hormone and cytokine receptors. All chapters and bibliographies from the second edition have been expanded to include the most recent literature in these areas. In addition, the text provides a new chapter which is the first to compare the three-dimensional structures of cytokines and hormones complexed with their receptors. As the only text to provide an up-to-the-minute account of the cellular, molecular and structural mechanisms of communication between the immune and neuroendocrine systems, this well-written volume will be of interest to many scientists in the fields of immunology, endocrinology, physiology, neuroscience and structural biology, and will also be a valuable resource for clinicians. |
Sommario
Production of Peptide Hormones and Neurotransmitters by | 1 |
Hypothalamic Releasing Factors | 7 |
Processing of LeukocyteDerived Peptide Hormones | 15 |
Acknowledgments | 23 |
Influence on Glial Cell Gene Expression and Function | 31 |
Oligodendrocytes | 37 |
Expression of Adhesion Molecules | 50 |
Structural Biology of Cytokines Their Receptors | 76 |
Neuroendocrine Peptide Receptors on Cells of the Immune System | 132 |
InsulinLike Growth Factor Receptor | 146 |
Introduction | 155 |
Vasoactive Intestinal Peptide | 168 |
Hormonal Activities of Cytokines | 185 |
Acknowledgments | 198 |
Signaling Models | 211 |
Author Index | 223 |
Noradrenergic and Peptidergic Innervation of Lymphoid Organs | 99 |
Functional Significance of Innervation | 119 |
Parole e frasi comuni
Acad Sci USA ACTH activity amino acid antibody antigen astrocytes Bellinger DL binding Biol Blalock Brain Behav Immun CD4+ T cells cell line cellular class II MHC Clin complex cytes differentiation effects Endocrinology endorphins enhanced Felten DL Felten SY gene expression glial cells GM-CSF growth factor growth hormone IFN-y immune function immune response immune system Immunol immunological immunoreactive induced inhibit innervation interactions interferon interleukin kinase leukocytes loops lymph nodes lymphocytes macrophages mediated mice microglia mitogen modulation molecular molecules monocytes mouse mRNA murine Natl Acad Sci nerve fibers nervous system neuroendocrine Neuroimmunol neurons neuropeptides Neurosci neurotransmitter noradrenergic oligodendrocytes opioid receptor pathway pituitary cells POMC Proc Natl Acad production prolactin receptor proliferation protein regulation release role secretion signal somatostatin spleen splenic ẞ-endorphin stimulation structure studies substance suppression T-cell thymocytes thymus TNF-a tumor necrosis vasoactive intestinal peptide vitro vivo