The explosion of information on immuneneuroendocrine interactions has continued unabated since the first and second editions of this volume appeared in 1988 and 1992. This third revised and enlarged edition offers an authoritative update on the latest advances in knowledge of the molecular, structural, and cellular bases of bidirectional communication between the immune and neuroendocrine systems. The eight invited chapters review current evidence that the immune system produces and responds to neuroendocrine peptide hormones and neurotransmitters; that the nervous system produces and responds to cytokines; that the immune system can regulate the neuroendocrine system and vice versa; that the immune system is innervated, and that the neuroendocrine and immune systems share a set of hormone and cytokine receptors. All chapters and bibliographies from the second edition have been expanded to include the most recent literature in these areas. In addition, the text provides a new chapter which is the first to compare the three-dimensional structures of cytokines and hormones complexed with their receptors. As the only text to provide an up-to-the-minute account of the cellular, molecular and structural mechanisms of communication between the immune and neuroendocrine systems, this well-written volume will be of interest to many scientists in the fields of immunology, endocrinology, physiology, neuroscience and structural biology, and will also be a valuable resource for clinicians.
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Regulation of LeukocyteDerived Peptide Hormones
Immunologic Cell Types that Produce Peptide Hormones
Expression of Adhesion Molecules
Structural Biology of Cytokines Their Receptors
Noradrenergic and Peptidergic Innervation of Lymphoid Organs
Functional Significance of Innervation
Hormonal Activities of Cytokines E M Smith Galveston Tex 185 Introduction
New Hormonal Activities
IL1 190 IL2 191 IL6 191 IL10 195 Tumor Necrosis Factor 195 Various Cytokines
Clinical Studies and Implications
Acknowledgments 198 References
Interactive Signaling Pathways of the NeuroendocrineImmune Network TL Roszman W H Brooks Lexington Ky 203 Introduction
Neuroendocrine Peptide Receptors on Cells of the Immune System
InsulinLike Growth Factor Receptor
Neuroendocrine Peptide Hormone Regulation of Immunity B A Torres H M Johnson Gainesville Fla 155 Introduction
POMC and Proenkephalin Products
ThyroidStimulating Hormone Thyrotropin TSH and Related Hormones
Vasoactive Intestinal Peptide
Conclusions 176 Acknowledgments
Can the Pituitary Gland Modulate the Immune System?
Are There Receptors for Neurohormones NH Present on Cells of the Immune System?
Can NH Influence the Immune System?
How Do NH Modulate TCell Function?
NH Modulation of Immune Function Future Directions
Acad Sci USA ACTH activity amino acid antibody antigen astrocytes B-endorphin Bellinger DL binding Biol Blalock Brain Behav Immun CD4+ T cells cell line cellular class II MHC Clin complex cytes differentiation disease effects Endocrinology endogenous endorphins enhanced Felten DL Felten SY gene expression glial cells GM-CSF growth hormone human peripheral blood IFN-Y immune function immune response immune system Immunol immunological immunoreactive induced inhibit innervation interactions interferon interleukin leukocytes lymph nodes lymphocytes macrophages mediated mice microglia mitogen modulation molecular molecules monocytes mouse mRNA murine Natl Acad Sci nerve fibers nervous system neuroendocrine Neuroimmunol neurons neuropeptides Neurosci neurotransmitter noradrenergic oligodendrocytes pathway pituitary cells POMC Proc Natl Acad production prolactin receptor proliferation protein regulation release role secretion signal somatostatin spleen splenic stimulation structure studies substance suppression synthesis T-cell TGF-B thymocytes thymus tissue tumor necrosis vasoactive intestinal peptide vitro vivo