The explosion of information on immuneneuroendocrine interactions has continued unabated since the first and second editions of this volume appeared in 1988 and 1992. This third revised and enlarged edition offers an authoritative update on the latest advances in knowledge of the molecular, structural, and cellular bases of bidirectional communication between the immune and neuroendocrine systems. The eight invited chapters review current evidence that the immune system produces and responds to neuroendocrine peptide hormones and neurotransmitters; that the nervous system produces and responds to cytokines; that the immune system can regulate the neuroendocrine system and vice versa; that the immune system is innervated, and that the neuroendocrine and immune systems share a set of hormone and cytokine receptors. All chapters and bibliographies from the second edition have been expanded to include the most recent literature in these areas. In addition, the text provides a new chapter which is the first to compare the three-dimensional structures of cytokines and hormones complexed with their receptors. As the only text to provide an up-to-the-minute account of the cellular, molecular and structural mechanisms of communication between the immune and neuroendocrine systems, this well-written volume will be of interest to many scientists in the fields of immunology, endocrinology, physiology, neuroscience and structural biology, and will also be a valuable resource for clinicians.
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Production of Peptide Hormones and Neurotransmitters by
Hypothalamic Releasing Factors
Processing of LeukocyteDerived Peptide Hormones
Influence on Glial Cell Gene Expression and Function
Tumor Necrosis Factora
Cytokine Effects on Astrocytes
Conclusions 176 Acknowledgments
Hormonal Activities of Cytokines E M Smith Galveston Tex 185 Introduction
New Hormonal Activities
IL1 190 IL2 191 IL6 191 IL10 195 Tumor Necrosis Factor 195 Various Cytokines
Clinical Studies and Implications
Class I MHC Expression
Structural Biology of Cytokines Their Receptors
Noradrenergic and Peptidergic Innervation of Lymphoid Organs
Functional Significance of Innervation
Neuroendocrine Peptide Receptors on Cells of the Immune System
InsulinLike Growth Factor Receptor
Neuroendocrine Peptide Hormone Regulation of Immunity B A Torres H M Johnson Gainesville Fla 155 Introduction
POMC and Proenkephalin Products
ThyroidStimulating Hormone Thyrotropin TSH and Related Hormones
Vasoactive Intestinal Peptide
Acknowledgments 198 References
Interactive Signaling Pathways of the NeuroendocrineImmune Network T L Roszman W H Brooks Lexington Ky 203 Introduction
Can the Pituitary Gland Modulate the Immune System?
Are There Receptors for Neurohormones NH Present on Cells of the Immune System?
Can NH Influence the Immune System?
How Do NH Modulate TCell Function?
NH Modulation of Immune Function Future Directions
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