NMR Studies of the Solution Conformation and Dynamics of the Tyrocidine Peptide AntibioticsUniversity of Wisconsin--Madison, 1985 - 552 pagine |
Sommario
Tyrocidines | 3 |
NMR spectroscopy in peptide solution conformation | 13 |
Experimental | 14 |
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Parole e frasi comuni
2D NOE experiment 9 Gln alpha carbon alpha protons alpha region amino acid anomalous chemical shifts Asn NH Asn side chain Asn³ assignments B-turn backbone structure beta protons Biochem Biochemistry carbon NT carbonyl Chap Chem contour plot correlation experiment coupling constants cross peaks decoupling experiments detected dihedral angles DMSO DMSO-d double resonance downfield shifted DPhe DTrp dynorphin experiment of tyrocidine experimental Gibbons Gln NH gramicidin hydrogen bond Hz/point interaction irradiating Leu³ methyl molecular molecule natural abundance NH proton NH-Ha Niccolai nitroxide NMR spectra NMR studies NOE data NOE values numbers Orn² overlap proton chemical shifts proton NMR random coil peptide relaxation rates residues rotamer rotamer populations rotation side chain side chain carbon side chain protons solution solvent spectroscopy spectrum spin spin-lattice relaxation Table TEMPO tion tyro C tyro tyroci tyrocidine upfield upfield shifted Val¹ Wüthrich X₁ rotamer нва