Oral Colon-Specific Drug DeliveryCRC Press, 27 lug 1992 - 288 pagine Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon. |
Sommario
Chapter | 2 |
Gastrointestinal Secretion and Absorption Enzymology | 11 |
Conclusions | 35 |
A Critical Review | 45 |
Chapter 3 | 85 |
Oral ColonSpecific Drug Delivery with Emphasis on Insulin | 115 |
Chapter 5 | 132 |
Chapter 6 | 153 |
Chapter 7 | 189 |
Dextran Prodrugs for ColonSpecific Drug Delivery | 213 |
Chapter 9 | 233 |
Parole e frasi comuni
5-aminosalicylic acid absorbed anaerobic animals B-D-glucosidase bacteria Bacteroides bile bioadhesive Biochem blood bowel capsules carriers cecal cecum Chem chondroitin cleavage Clin colon-specific drug delivery colonic delivery colonic drug delivery compounds contents copolymers decrease degradation delivery system dexamethasone dextran dextran conjugates diabetic digestion disease distal dosage forms dose drug absorption drug delivery drug release effect enhancers enterocytes enzymatic enzymes epithelial cells Figure flora gastric emptying Gastroenterology gastrointestinal tract GI tract glucose glycosidase activity glycosidases glycosides guinea pig HPMA copolymers human colon hydrolysis hydrolyzed ileum increased insulin intracellular Kopeček large intestine levels liver lumen luminal lymphatic lysosomal membrane metabolism microbial microflora molecular weight molecules motility mucosa naproxen oligopeptide olsalazine oral administration pancreatic peptide Pharm Pharmacol Physiol plasma polymer polymeric potential prodrugs produce protein proximal colon rabbit reduced secretion small intestine sodium specific stomach studies substrates sulfasalazine tissue transport ulcerative colitis uptake vitro vivo
Riferimenti a questo libro
Biodegradable Hydrogels for Drug Delivery Haesun Park,Kinam Park,Waleed S.W. Shalaby Anteprima limitata - 2011 |