ApoptosisMichael D. Jacobson, Nicola J. McCarthy Oxford University Press, 2002 - 321 pagine Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps. |
Sommario
Why be interested in death? | 1 |
Models of apoptosis | 14 |
the genetic | 23 |
Genetic and molecular analysis of programmed cell death | 56 |
Transcriptional regulation of the reaper gene | 63 |
Drosophila caspases | 71 |
How do the cell death regulators rpr hid and grim induce cell death | 74 |
Inhibition of pathological cell death | 81 |
Xenopus egg extracts | 186 |
Acknowledgements | 194 |
Death signalling by the CD95TNFR family | 200 |
Ligands of the TNF receptor superfamily | 209 |
Regulation of death receptorinduced killing | 217 |
Conclusion | 224 |
PDK1independent mechanisms of Akt activation | 242 |
Viruses and apoptosis | 262 |
consequential cleavage | 93 |
Regulation of apoptosis by the Bcl2 family | 136 |
| 149 | |
recent discoveries on Bc12 family proteins | 156 |
Pandoras Box | 161 |
Heat shock proteins | 167 |
lessons from cellfree systems | 176 |
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Acad anti-apoptotic apoptotic cells baculovirus Bcl-2 family Bcl-2 family proteins Bcl-xL binding biochemical Caenorhabditis elegans cascade caspase activation caspase inhibitor caspase-3 Cell Biol cell corpses cell cycle cell survival cell-free systems cellular Chem cleavage cleaved complex cytochrome cytochrome c release cytokine cytoplasmic cytosol death domain DIAP1 disease downstream DRONC Drosophila EMBO encodes engulfment expression FADD function gene genetic granzyme homologue Horvitz human identified induce apoptosis inhibit interaction intracellular involved ligand mammalian cells mechanism mediated mice mitochondrial mitochondrial membrane molecular molecules mutations N-terminal Natl nematode neurons neurotrophin NF-kB nuclear oligomerization Oncogene overexpression phenotype phosphorylation PI3K pro-apoptotic Proc procaspases programmed cell death protease protein kinase reaper regulation release of cytochrome response role sequence signalling pathways specific studies substrates suggesting survival signals target tissues translocation trigger tumour tumour necrosis factor viral vitro Wang