Clinical NeuroimmunologyJack P. Antel Oxford University Press, 2005 - 452 pagine Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way. |
Sommario
1 Introduction to immunology | 1 |
2 Principles of autoimmunity | 13 |
3 Principles of immunotherapy | 21 |
4 Organization and development of the central nervous system | 33 |
5 Immune properties of the central nervous system | 43 |
6 Role of the immune response in tissue damage and repair in the injured spinal cord | 53 |
7 Neural immune interactions in inflammatoryautoimmune disease | 65 |
8 Immunological properties of the peripheral nervous system | 77 |
19 GuillainBarré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy | 229 |
20 Antibodymediated disorders of the neuromuscular junction | 239 |
21 Immunemediated mechanisms in inflammatory myopathies | 259 |
22 The neuroimmunology of HIV infection | 271 |
23 HTLVI infection and the nervous system | 285 |
24 Lyme neuroborreliosis | 301 |
25 Paraneoplastic syndromes | 315 |
26 Neuropathies associated with monoclonal gammopathy | 327 |
9 Genetics of immunemediated neurological diseases | 87 |
10 Principles of immunevirus interactions in the nervous system | 103 |
11 Immunity to bacterial infections | 115 |
129 | |
13 Acute disseminated encephalomyelitis | 147 |
14 Tissue pathology of multiple sclerosis | 173 |
15 The immunology of multiple sclerosis | 185 |
16 Imaging the immunobiology of multiple sclerosis | 195 |
effects of immune mediators on neurophysiological function | 209 |
18 Multiple sclerosisimmunedirected therapy | 217 |
27 NeuroBehçets syndrome | 339 |
28 Role of neuralimmune interactions in neurodegenerative diseases | 355 |
29 Central nervous system neoplastic diseases and the immune system | 365 |
30 Vasculitides of the nervous system | 381 |
31 Myelin repair in multiple sclerosis | 399 |
32 Immunological aspects of ischemic stroke | 403 |
413 | |
a personal perspective | 425 |
447 | |
Altre edizioni - Visualizza tutto
Clinical Neuroimmunology Jack Antel,Gary Birnbaum,Hans-Peter Hartung,Angela Vincent Anteprima limitata - 2005 |
Parole e frasi comuni
Acad Sci USA AChR activation acute ADEM Ann Neurol antibodies antigen apoptosis associated astrocytes autoimmune disease autoimmune encephalomyelitis axonal brain burgdorferi CD4+ CD8+ T cells cellular central nervous system chemokines chronic Clin clinical complement cytokines cytotoxic Dalakas demyelination effects endothelial cells epitope experimental autoimmune experimental autoimmune encephalomyelitis expression factors function gene genetic glucocorticoid HAM/TSP HTLV-I human immune response immune system immunoglobulin Immunol immunological increased induced infection infiltration inflammation inflammatory involvement lesions ligand Lyme lymphocytes macrophages mechanisms mediated mice microglia molecular molecules monoclonal multiple sclerosis muscle myasthenia gravis myelin basic protein Natl Acad Sci nerve neuritis Neuroimmunol neuropathy Neurosci neutrophils oligodendrocytes paraneoplastic pathogenesis pathogenic patients peptide peripheral Proc Natl Acad protein receptor role serum specific spinal cord studies symptoms syndrome T-cell target therapy tion tissue transgenic treatment tumor vaccination viral virus type vitro vivo white matter