Clinical Neuroimmunology

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Jack P. Antel, Gary Birnbaum, Hans-Peter Hartung, Angela Vincent
Oxford University Press, 2005 - 452 pagine
Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches todisease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chaptersare dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to awhole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinicalneuroimmunology in a comprehensive and unbiased way.
 

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Indice

1 Introduction to immunology
1
2 Principles of autoimmunity
13
3 Principles of immunotherapy
21
4 Organization and development of the central nervous system
33
5 Immune properties of the central nervous system
43
6 Role of the immune response in tissue damage and repair in the injured spinal cord
53
7 Neural immune interactions in inflammatoryautoimmune disease
65
8 Immunological properties of the peripheral nervous system
77
19 GuillainBarré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
229
20 Antibodymediated disorders of the neuromuscular junction
239
21 Immunemediated mechanisms in inflammatory myopathies
259
22 The neuroimmunology of HIV infection
271
23 HTLVI infection and the nervous system
285
24 Lyme neuroborreliosis
301
25 Paraneoplastic syndromes
315
26 Neuropathies associated with monoclonal gammopathy
327

9 Genetics of immunemediated neurological diseases
87
10 Principles of immunevirus interactions in the nervous system
103
11 Immunity to bacterial infections
115
12 Animal models of neurologic disease
129
13 Acute disseminated encephalomyelitis
147
14 Tissue pathology of multiple sclerosis
173
15 The immunology of multiple sclerosis
185
16 Imaging the immunobiology of multiple sclerosis
195
effects of immune mediators on neurophysiological function
209
18 Multiple sclerosisimmunedirected therapy
217
27 NeuroBehçets syndrome
339
28 Role of neuralimmune interactions in neurodegenerative diseases
355
29 Central nervous system neoplastic diseases and the immune system
365
30 Vasculitides of the nervous system
381
31 Myelin repair in multiple sclerosis
399
32 Immunological aspects of ischemic stroke
403
33 Antibodies and CNS disorders
413
a personal perspective
425
Index
447
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Informazioni sull'autore (2005)

Jack Antel is at Professor, Depratment of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada. Gary Birnbaum is at Minneapolois Clinic of Neurology, Mineapolis, USA.

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