PharmacologyChurchill Livingstone, 2001 - 839 pagine Adapted for the U.S., this New Edition of PHARMACOLOGY, a popular UK text, describes what drugs do and emphasizes the mechanisms by which they act. The U.S. edition is revised and updated to reflect the substantial differences in drug names, FDA approvals, terminology, and guidelines for use. It also boasts new and revised chapters to ensure that students are up to date on the very latest information. Each chapter begins with a summary of information essential to the chapter and key points are highlighted within the text to alert students to crucial concepts. Spanish version also available, ISBN: 84-8174-492-1 |
Dall'interno del libro
Risultati 1-3 di 18
Pagina 401
... leptin . A and B The effect of a single i.v. injection on food intake in ob / ob and lean mice . C The effect on ... leptin. Food intake ( g ) A 2 i.v. injection ob / ob mice Saline 1.5 Vehicle 0.5 Leptin Food intake ( g ) i.v. injection ...
... leptin . A and B The effect of a single i.v. injection on food intake in ob / ob and lean mice . C The effect on ... leptin. Food intake ( g ) A 2 i.v. injection ob / ob mice Saline 1.5 Vehicle 0.5 Leptin Food intake ( g ) i.v. injection ...
Pagina 402
H. P. Rang. Plasma leptin ( ng / ml ) 100 10 D ↑ Leptin release Hypothalamus NPY ↑ CRF Gcs increase ENERGY EXPENDITURE 0.1 15 20 25 30 35 40 45 Body mass index ( kg / m2 ) leptin expression Adipocytes Fig . 23.2 Relation between body ...
H. P. Rang. Plasma leptin ( ng / ml ) 100 10 D ↑ Leptin release Hypothalamus NPY ↑ CRF Gcs increase ENERGY EXPENDITURE 0.1 15 20 25 30 35 40 45 Body mass index ( kg / m2 ) leptin expression Adipocytes Fig . 23.2 Relation between body ...
Pagina 405
... leptin concentration Leptin concentration proportional to fat mass in both . Rate of leptin production per unit of adipose mass and rate of leptin clearance from the circulation similar in both Decreases with weight loss , then ...
... leptin concentration Leptin concentration proportional to fat mass in both . Rate of leptin production per unit of adipose mass and rate of leptin clearance from the circulation similar in both Decreases with weight loss , then ...
Sommario
general principles | 11 |
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
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5-HT receptors absorption acetylcholine action potential activity adrenoceptors agents agonists amino acids anesthetics antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ cancer cardiac cause cells chemical cholinergic clinical compounds cytokines decrease depolarization depression disease diuretics dopamine dose drugs enzyme estrogens ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals neurons nicotine norepinephrine normal occurs opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma concentration platelet presynaptic produce prostaglandins protein reactions receptor antagonists reduced release renal response result role secretion side-effects smooth muscle sodium stimulation substance sympathetic synaptic synthesis therapeutic therapy tissue toxicity transmission transmitter treatment tubule unwanted effects uptake vascular vasoconstriction vitamin