Osteoarthritis, Inflammation and Degradation: A Continuum
"Osteoarthritis is a major public health issue due to its impact in term of handicap. Moreover, Ageing of the world population and outbreak of obesity in industrialized and non-industrialized countries will dramatically increase its incidence in the next years. Regarded as a multi-factorial disease, today mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. In order to collect major information in a benchmark book on the fundamental aspects of this disease, internationally well-known authors, from multiple specialties, gathered to analyse, dissect and finally try to understand the secrets of a disease which should no more be regarded as the common and relentless result of ageing or of passive wear but much more as an active disease able to benefit from the best targeted pharmacological (anti-cytokines, inhibitors of signalling pathways, inhibitors of proteases, etc.) and non-pharmacological (cellular therapy, gene therapy, cartilage engineering etc.) therapies, current and future."
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Effectors and Different Pathways
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acid activity aggrecan anabolic apoptosis Arthritis Rheum articular cartilage binding Biol Chem bovine carti cartilage degradation cartilage explants cartilage matrix catabolic cells chondro chondrocytes chondrogenesis Clin clinical collagen collagenase cultured cytokines disease effects enhanced enzymes extracellular matrix fibronectin fibronectin fragments fluorescence Fn-fs gene expression growth factor human articular chondrocytes human chondrocytes Human in vitro human osteoarthritic imaging increased induced inflammation inflammatory inhibition inhibitors integrin interactions interleukin-1 isoforms joint knee leptin levels MAP kinase markers Martel-Pelletier matrix metalloproteinase mechanical mediators membrane metabolism microscopy mitochondrial modulate molecular mPGES-1 mRNA nitric oxide normal OA cartilage Orthop osteoarthritis Osteoarthritis Cartilage Pelletier JP PGE2 phenotype PPAR production proinflammatory promoter prostaglandin E2 protein kinase proteoglycan receptor regulation response Rheum Rheumatol role serum signaling pathways Sox9 stimulated studies subchondral bone suppression synovial fibroblasts synovial fluid synoviocytes synovium synthase synthesis tion tissue transcription factor type II collagen upregulated vivo