Cell Adhesion

Copertina anteriore
Mary C. Beckerle
Oxford University Press, 2001 - 403 pagine
Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour. The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed. Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers.
 

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Indice

The immunoglobulin superfamily of cell adhesion
1
Expression of IgCAMs
7
IgCAM function in vivo
19
Selectins
30
Mechanisms for selectinmediated cell adhesion under flow conditions
38
Signalling through selectins or selectin ligands
47
Conclusions
53
Cadherins
62
Role in cell adhesion
225
Identification of RPTPdependent signalling pathways
231
Physiological functions of RPTPs
240
Emerging concepts
244
The adherens junction
259
Assembly of junctions
269
Communication between the junctional complex and the nucleus
272
Emerging concepts
278

Developmental regulation of cadherin subtypes
71
Genetic analysis of cadherincatenin complex in mice
78
Genetic regulation of cadherin function
86
The integrin family of cell adhesion molecules
100
Integrin signalling
113
Cell biological consequences of integrin functions
118
Integrins in development
125
Integrins in disease
134
Cell surface heparan sulfate proteoglycans
155
Cell adhesion mediated by cell surface heparan sulfate proteoglycans
164
Cellular consequences of HSFGmediated adhesion
170
Acknowledgements
179
ADAMs
189
possible roles in cell adhesion
205
Expression patterns
221
Focal adhesions and focal complexes
288
Integrincytoskeletal links
299
Hierarchical structure of focal adhesions
305
Concluding remarks
311
Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer
313
Desmosomes and hemidesmosomes
324
The desmosome
325
The hemidesmosome
339
Conclusion
351
The tight junction
369
A possible model for the molecular architecture of tight junctions
380
Signalling events at the cytoplasmic surface of tight junctions
386
Index
397
Copyright

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Informazioni sull'autore (2001)

Mary Beckerle is at Huntsman Cancer Institute and Department of Biology, University of Utah, USA.

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