Cell AdhesionMary C. Beckerle Oxford University Press, 2001 - 403 pagine Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour. The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed. Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers. |
Sommario
The immunoglobulin superfamily of cell adhesion | 1 |
63 | 3 |
Expression of IgCAMs | 7 |
Selectins | 30 |
Regulation of expression of selectins and selectin ligands | 43 |
8 | 51 |
RADICE | 62 |
Developmental regulation of cadherin subtypes | 71 |
possible roles in cell adhesion | 205 |
Expression patterns | 221 |
Role in cell adhesion | 225 |
Identification of RPTPdependent signalling pathways | 231 |
Physiological functions of RPTPs | 240 |
Emerging concepts | 244 |
The adherens junction | 259 |
Assembly of junctions | 269 |
Cadherins | 76 |
8 | 87 |
Center for Research on Reproduction and Womens Health Department of Obstetrics | 92 |
Introduction | 100 |
Cell biological consequences of integrin functions | 118 |
Integrin signalling | 122 |
Integrins in development | 125 |
31 | 132 |
Integrins in disease | 134 |
43 | 138 |
Cell surface heparan sulfate proteoglycans | 155 |
Cell adhesion mediated by cell surface heparan sulfate proteoglycans | 164 |
Cellular consequences of HSPGmediated adhesion | 170 |
179 | |
ADAMS | 189 |
Communication between the junctional complex and the nucleus | 272 |
Emerging concepts | 278 |
Focal adhesions and focal complexes | 288 |
Integrincytoskeletal links | 299 |
Hierarchical structure of focal adhesions | 305 |
Concluding remarks | 311 |
Desmosomes and hemidesmosomes | 324 |
The desmosome | 325 |
The hemidesmosome | 339 |
Conclusion | 351 |
The tight junction | 369 |
A possible model for the molecular architecture of tight junctions | 380 |
Signalling events at the cytoplasmic surface of tight junctions | 386 |
397 | |
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actin activity adherens junctions affinity amino acid antibodies assembly associated axonin-1 axons B-catenin beta carcinoma catenin cell adhesion molecule Cell Biol cell-cell adhesion cellular Chem classical cadherins clustering complex components cytoplasmic cytoplasmic domain cytoplasmic tail cytoskeleton desmosomal differentiation dimerization disintegrin disintegrin domains Drosophila E-cadherin embryos endothelial cells epithelial cells expression extracellular domain extracellular matrix F11/contactin fibroblasts fibronectin filaments focal adhesions function gastrulation gene GlyCAM-1 glycoprotein growth factor hemidesmosomes Ig-like domains IgCAMs induces inhibited integrin interactions involved isoforms juxtamembrane laminin leukocyte ligand ligand binding mediated mesoderm mice molecular mouse mutations N-terminal Natl NCAM neural neurite outgrowth neurofascin neurons NrCAM occludin P-selectin peptide phenotype phosphorylation plakoglobin plasma membrane platelets protein tyrosine phosphatase receptor region regulation residues RhoA role RPTPs selectins sequence specific stress fibres structure subfamily substrate subunit suggest sulfate syndecan-1 syndecans tissues tumour tyrosine phosphorylation vinculin vitro vivo Xenopus