Ig Superfamily Molecules in the Nervous SystemCRC Press, 2 set 2003 - 328 pagine A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided. |
Sommario
1 STRUCTURAL FEATURES OF NEURAL IMMUNOGLOBULIN SUPERFAMILY ADHESION MOLECULES | 1 |
2 MOLECULAR INTERACTIONS INVOLVING IMMUNOGLOBULIN SUPERFAMILY ADHESION PROTEINS | 23 |
3 NCAM POLYSIALIC ACID | 57 |
4 SIGNAL TRANSDUCTION NEURITE GROWTH AND IgSUPERFAMILY ADHESION MOLECULES IN THE VERTEBRATE NERVOUS SYST... | 75 |
5 IgSUPERFAMILY KINASES | 101 |
6 IgSUPERFAMILY PHOSPHATASES | 133 |
7 MOLECULAR MECHANISMS OF GROWTH CONE GUIDANCE IN THE VERTEBRATE NERVOUS SYSTEM | 161 |
8 GENETIC ANALYSIS OF THE FASCICLIN H CELL ADHESION MOLECULE REVEALS MULTIPLE ROLES DURING THE GENERATION O... | 183 |
9 NEURAL CELL ADHESION MOLECULES IN ACTIVITYDEPENDENT PLASTICITY | 205 |
10 IgSUPERFAMILY MOLECULES IN NEURAL REGENERATION IN THE CNS | 235 |
11 IgSUPERFAMILY MOLECULES IN MYELINATION AND REGENERATION IN THE PERIPHERAL NERVOUS SYSTEM | 261 |
12 MEDICAL GENETICS OF Ig SUPERFAMILY MOLECULES | 287 |
305 | |
Altre edizioni - Visualizza tutto
Parole e frasi comuni
acid activity adult antibodies appears associated axonin-1 axons binding Biol brain cadherins CAMs cell adhesion molecule changes Chem complex containing cytoplasmic differentiation domain Drosophila effects embryonic et al evidence experiments expression extracellular fasciculation Figure fold formation function gene glycoprotein growth cone guidance homophilic Ig superfamily IgSF immunoglobulin important increase indicate induced inhibits integrin interactions involved levels ligand mechanism mediated membrane mice migration modulate molecular motor mouse muscle mutations myelin Nature NCAM nerve nervous system neural cell adhesion neurite outgrowth neurons Neurosci NgCAM normal observed optic pathway pattern peripheral phosphorylation plasticity potentiation present promoting protein recent receptor receptor tyrosine recognition regeneration region regulation response retinal RGCs role Schachner Schwann cells segment shown signaling similar specific stimulated structure studies suggest surface synaptic transmembrane tyrosine kinase tyrosine phosphatase vitro vivo