In Vitro Methods in Developmental Toxicology: Use in Defining Mechanisms and Risk ParametersCRC Press, 30 nov 1989 - 192 pagine This text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development. |
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abnormal Acad activity agents alter antibodies assay Biochem cadmium cell adhesion Cell Biol cell death cell migration cell proliferation cell surface cell types cell-cell cellular chick embryo chondrocytes collagen concentrations cyclic AMP developmental toxicity differentiation drug dye transfer effects embryo embryo culture embryonic palate epithelial epithelium etretinate explants exposure extracellular matrix fetal fibroblasts fibronectin fluorescence gap junctions gene glucocorticoids growth factor Gynecol hormones induced inhibition interactions isotretinoin junctional communication Kochhar laminin levels limb bud maternal mechanisms medium membrane mesenchyme cells morphogenesis Morphol mouse embryo Natl Nature London neural crest cells normal Obstet palate mesenchyme cells perfusion Pharmacokinetics Pharmacol phospholipase placenta plasma potential Pratt Proc promoter prostaglandins protein radiolabeled receptor regulation regulatory retinoic acid retinoids role secondary palate serotonin specific studies substances synthesis techniques Teratogenesis teratogenic Teratology testing tissue trophoblast Trophoblast Res uptake valproic acid vitro vitro systems vivo