Antibiotics: Origin, Nature, and Properties, Volume 1

acetone acid hydrolysis actinomycete active against gram-positive active in vitro alkaline amicetin amino acid Annu anti antibacterial antibiotic antibiotic produced Antibiotiki Antimicrob aqueous solution Argoudelis ATCC bacteria benzene biological activity biosynthesis biotic biuret capreomycin CH₂ Chem Chemother chloroform complex components compound concentrations coumermycin crystallized decomp doses elution erythromycin Escherichia coli ethyl acetate Fehling fermentation broth filtrate filtrate by extraction gentamicin give absorption maxima gram-negative gram-negative microorganisms gram-positive gram-positive microorganisms hydrochloride hydrolysis ilamycin inactivated inhibits insoluble intraperitoneally intravenously isolated from fermentation kanamycin LD50 for mice leucomycin lincomycin methanol Methanolic solutions mg/kg mice infected mikamycin molecular weight molecule Molisch mycelium mycin Mycobacterium neomycin NH₂ ninhydrin novobiocin OH OH petroleum ether pneumoniae precipitated produced by Streptomyces purified R₁ R₂ Sakaguchi soluble in water spectrum Staphylococcus aureus strain Streptomyces Streptococcus Streptomyces Streptomyces sp streptothricin structure studies subcutaneously substance synthesis tetracycline toxic Umezawa H viomycin vivo µg/ml