Alternatives to Laboratory Animals: ATLA., Volume 37

active ADMET angiogenesis antibody apoptosis approach assays assessment bioavailability biopsies Biopta blood vessels Cancer Research cell culture cell line clinical trials compound concentrations cytokine cytotoxic dendritic cells discovery and development Discovery discussion meeting donors dose drug candidates drug development Drug Discovery Drug Discovery discussion drug metabolism drug safety effects efficacy Figure functional gene expression HEPG2/C3A cells high-throughput hosted by Safer human tissue Human Tissue Authority Hurel device immune response interactions ISIS Journal liver compartment lung measure microdialysis microdosing microfluidic MIMIC System mitochondrial toxicants Müller naphthalene organ parameters patients PBMC peripheral Pharma pharmaceutical pharmacokinetics Pharmacology Phase phospholipidosis physiological plasma preclinical predict profiles proteins PTE module reactive metabolites Safer Medicines Trust Safety in Drug SimuGen skin specific Speed and Safety studies sulindac sunitinib sunitinib malate T-cell target techniques technologies tegafur therapeutic tion toxicogenomics toxicology tumour V79 cells vaccine vascular virtual clinical trials vitro vivo