Hematopoiesis: A Developmental Approach

Copertina anteriore
Leonard I. Zon
Oxford University Press, 12 apr 2001 - 56 pagine
Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.
 

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Indice

Some General Aspects of Hematopoietic Cell Development
3
Stem Cells and Hematolymphoid Development
15
Stem Cell Populations Purification and Behavior
35
Regulation of Hematopoietic Stem Cells Some Conceptual and Practical Considerations
48
The Lineage Commitment and SelfRenewal of Blood Stem Cells
61
Blast Cell Colony Assays
82
Quantitative Studies of Normal and Leukemic Stem Cells Definition and Regulation
85
Normal and Leukemic Human Stem Cells Assayed in ImmuneDeficient Mice
99
Homeobox Gene Networks and the Regulation of Hematopoiesis
402
Myeloid Biology
415
Myeloid Transcription Factors and Development
417
Megakaryocyte Signaling
429
Transcription Factors Active in Megakaryocyte Development
443
The Role of the Thrombopoietin Receptor in Megakaryopoiesis
450
Mast Cell and Basophil Development
461
The Role of Osteoblasts in Hematopoietic Stem Cell Biology
476

Ex Vivo Expansion of Hematopoietic Stem Cells
119
Hematopoietic Stem Cell Gene Therapy Progress and Prospects
130
Early Embryology and Ontogeny
147
Zebrafish Hematopoietic Development
149
Blood Formation During Xenopus Embryogenesis
154
Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis
162
Developmental Relationship of Hematopoietic Stem Cells and Endothelial Cells
171
Ventral Yolk Sac Hematopoiesis in the Mouse
180
Dorsal Hematopoiesis in Fish and Amphibians
192
NonYolk Sac Hematopoietic Stem Cells The Avian Paradigm
201
Hematopoietic Stem Cell Development in Mammals
209
Changes in Lymphoid Progenitor Populations During Mammalian Development
218
Use of Embryonic Stem Cell In Vitro Differentiation in a SerumFree Environment for Analysis of Mesoderm Formation and Hematopoietic Develop...
229
Drosophila Hematopoiesis
236
Important Factors in Hematopoiesis
245
Regulation of Myelopoiesis as Assessed by Gene Deletion and Gene Transduction
247
Hematopoietic Signal Transduction
258
JakSTAT Signal Transduction
269
OxygenRegulated Erythropoietin Gene Expression
288
Involvement of Activins and TGFβs in Hematopoiesis
299
Wnts and Hematopoiesis
308
Notch Signaling During Hematopoiesis
323
Very Late Activationβi Integrins in Hematopoiesis
337
Chemokines
343
Transcriptional Control During Erythroid and Megakaryocytic Development
348
Transcription Factors That Induce Commitment of Multipotent Hematopoietic Progenitors Lessons from the MEP System
355
Regulatory Interactions Between Transcription Factors and Their Role in Hematopoietic Lineage Determination
363
Nuclear Receptors in Hematopoietic Development Cooperation with Growth Factor Receptors in Regulation of Proliferation and Differentiation
368
Ets Transcription Factor Mutations and Hematopoiesis
391
Lymphoid Biology
485
The Role of Ikaros Proteins in Lymphocyte Development and Function
487
Trcmscriptional Regulation of T Cell Development and Activation
496
Signal Transduction in Thymus Development
507
Lineage Commitment of CD4+ T Helper Lymphocytes
519
B Cell Development and Maturation
529
Signal Transduction and Regulation of Antigen Receptor Gene Rearrangement During Early Lymphocyte Development
544
The Phylogenetic Development of the Cells That Express and the Mechanisms That Diversify Immunoglobulins and T Cell Antigen Receptors
565
Genetics of Blood Formation
575
Zebrafish Hematopoietic Mutants
577
Spontaneous and Targeted Mutations in Erythrocyte Membrane Skeleton Genes Mouse Models of Hereditary Spherocytosis
582
Human Bone Marrow Failure Syndromes
609
Hemoglobin Switching and Developmental Changes in Erythropoietic Sites and Red Blood Cell Populations of Nonmammalian Vertebrates
617
Hemoglobin Switching
638
Dominant WhiteSpotting and Steel Mutants in Hematopoiesis
647
Applications of LargeInsert Genomic Cloning to the Study of Hematopoiesis
663
Aberrant Control of Cell Fate in the Leukemias and Lymphomas
672
Stroma
689
Microenvironmental Cell Populations Essential for the Support of Hematopoietic Stem Cells
691
Mediators Involved in the Control of Hematopoiesis by the Microenvironment
702
The Development of Stromal Cells
718
Mouse Genetics for the Analysis of Stem Cell Behavior
727
Vasculogenesis
735
Receptor Tyrosine Kinases in Endothelial and Hematopoietic Cell Development
737
Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis
766
Regulation of Hematopoiesis by Bone Marrow Microvascular Endothelium
774
Vascular Matrix and Disorders
784
The Angiopoietins and How They Act Coordinately with Vascular Endothelial Growth Factor During Normal and Pathologic Angiogenesis
796
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