Hematopoiesis: A Developmental ApproachLeonard I. Zon Oxford University Press, 12 apr 2001 - 56 pagine Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells. |
Sommario
Some General Aspects of Hematopoietic Cell Development | 3 |
Stem Cells and Hematolymphoid Development | 15 |
Stem Cell Populations Purification and Behavior | 35 |
Regulation of Hematopoietic Stem Cells Some Conceptual and Practical Considerations | 48 |
The Lineage Commitment and SelfRenewal of Blood Stem Cells | 61 |
Blast Cell Colony Assays | 82 |
Quantitative Studies of Normal and Leukemic Stem Cells Definition and Regulation | 85 |
Normal and Leukemic Human Stem Cells Assayed in ImmuneDeficient Mice | 99 |
Homeobox Gene Networks and the Regulation of Hematopoiesis | 402 |
Myeloid Biology | 415 |
Myeloid Transcription Factors and Development | 417 |
Megakaryocyte Signaling | 429 |
Transcription Factors Active in Megakaryocyte Development | 443 |
The Role of the Thrombopoietin Receptor in Megakaryopoiesis | 450 |
Mast Cell and Basophil Development | 461 |
The Role of Osteoblasts in Hematopoietic Stem Cell Biology | 476 |
Ex Vivo Expansion of Hematopoietic Stem Cells | 119 |
Hematopoietic Stem Cell Gene Therapy Progress and Prospects | 130 |
Early Embryology and Ontogeny | 147 |
Zebrafish Hematopoietic Development | 149 |
Blood Formation During Xenopus Embryogenesis | 154 |
Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis | 162 |
Developmental Relationship of Hematopoietic Stem Cells and Endothelial Cells | 171 |
Ventral Yolk Sac Hematopoiesis in the Mouse | 180 |
Dorsal Hematopoiesis in Fish and Amphibians | 192 |
NonYolk Sac Hematopoietic Stem Cells The Avian Paradigm | 201 |
Hematopoietic Stem Cell Development in Mammals | 209 |
Changes in Lymphoid Progenitor Populations During Mammalian Development | 218 |
Use of Embryonic Stem Cell In Vitro Differentiation in a SerumFree Environment for Analysis of Mesoderm Formation and Hematopoietic Develop... | 229 |
Drosophila Hematopoiesis | 236 |
Important Factors in Hematopoiesis | 245 |
Regulation of Myelopoiesis as Assessed by Gene Deletion and Gene Transduction | 247 |
Hematopoietic Signal Transduction | 258 |
JakSTAT Signal Transduction | 269 |
OxygenRegulated Erythropoietin Gene Expression | 288 |
Involvement of Activins and TGFβs in Hematopoiesis | 299 |
Wnts and Hematopoiesis | 308 |
Notch Signaling During Hematopoiesis | 323 |
Very Late Activationβi Integrins in Hematopoiesis | 337 |
Chemokines | 343 |
Transcriptional Control During Erythroid and Megakaryocytic Development | 348 |
Transcription Factors That Induce Commitment of Multipotent Hematopoietic Progenitors Lessons from the MEP System | 355 |
Regulatory Interactions Between Transcription Factors and Their Role in Hematopoietic Lineage Determination | 363 |
Nuclear Receptors in Hematopoietic Development Cooperation with Growth Factor Receptors in Regulation of Proliferation and Differentiation | 368 |
Ets Transcription Factor Mutations and Hematopoiesis | 391 |
Lymphoid Biology | 485 |
The Role of Ikaros Proteins in Lymphocyte Development and Function | 487 |
Trcmscriptional Regulation of T Cell Development and Activation | 496 |
Signal Transduction in Thymus Development | 507 |
Lineage Commitment of CD4+ T Helper Lymphocytes | 519 |
B Cell Development and Maturation | 529 |
Signal Transduction and Regulation of Antigen Receptor Gene Rearrangement During Early Lymphocyte Development | 544 |
The Phylogenetic Development of the Cells That Express and the Mechanisms That Diversify Immunoglobulins and T Cell Antigen Receptors | 565 |
Genetics of Blood Formation | 575 |
Zebrafish Hematopoietic Mutants | 577 |
Spontaneous and Targeted Mutations in Erythrocyte Membrane Skeleton Genes Mouse Models of Hereditary Spherocytosis | 582 |
Human Bone Marrow Failure Syndromes | 609 |
Hemoglobin Switching and Developmental Changes in Erythropoietic Sites and Red Blood Cell Populations of Nonmammalian Vertebrates | 617 |
Hemoglobin Switching | 638 |
Dominant WhiteSpotting and Steel Mutants in Hematopoiesis | 647 |
Applications of LargeInsert Genomic Cloning to the Study of Hematopoiesis | 663 |
Aberrant Control of Cell Fate in the Leukemias and Lymphomas | 672 |
Stroma | 689 |
Microenvironmental Cell Populations Essential for the Support of Hematopoietic Stem Cells | 691 |
Mediators Involved in the Control of Hematopoiesis by the Microenvironment | 702 |
The Development of Stromal Cells | 718 |
Mouse Genetics for the Analysis of Stem Cell Behavior | 727 |
Vasculogenesis | 735 |
Receptor Tyrosine Kinases in Endothelial and Hematopoietic Cell Development | 737 |
Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis | 766 |
Regulation of Hematopoiesis by Bone Marrow Microvascular Endothelium | 774 |
Vascular Matrix and Disorders | 784 |
The Angiopoietins and How They Act Coordinately with Vascular Endothelial Growth Factor During Normal and Pathologic Angiogenesis | 796 |
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