Taxol: Science and Applications
This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
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A Brief History of the Yew Tree
Semisynthesis of Taxol and Taxotere
The Use of Taxol in Cell Biology
The Medicinal Chemistry of Taxol
10-deacetylbaccatin A-ring acid administered agents alkaloids antitumor activity Approach assay baccata baccatin biological C-ring callus carcinoma cell culture cell lines cephalomannine Chem chemical cisplatin clinical compound concentrations Cremophor cuspidata cycloaddition cytotoxicity derivatives dose drug effects ester esterification evaluated extraction Figure formation formulation fragmentation growth Guenard harvest human tumor hydroxyl injection isolated leukemia liposomes methyl mg/kg mice microtubule moiety murine Natl Oncol ovarian cancer oxetane oxidation Pacific yew Pacific yew bark Paclitaxel patients phase plant cell culture Potier precursor prodrugs reaction reported ring system schedule Scheme secondary metabolites semisynthesis sequence side chain solubility species STRATEGY LEVEL structure studies taxane taxane production taxoids Taxol Taxol analogues Taxol and Taxotere Taxol and Taxus Taxol content Taxol side chain Taxotere Taxus baccata Taxus brevifolia Tetrahedron Lett therapy tissue toxicity treatment trials tricycle tubulin tumor models vitro vivo Workshop on Taxol xenografts yew trees