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Numero di pubblicazioneEP1667729 A4
Tipo di pubblicazioneRichiesta
Numero domandaEP20040776088
numero PCTPCT/US2004/016246
Data di pubblicazione17 ott 2007
Data di registrazione20 mag 2004
Data di priorità23 mag 2003
Pubblicato anche comeCA2526853A1, EP1667729A2, WO2005018537A2, WO2005018537A3
Numero di pubblicazione04776088, 04776088.9, 2004776088, EP 1667729 A4, EP 1667729A4, EP-A4-1667729, EP04776088, EP1667729 A4, EP1667729A4, EP20040776088, PCT/2004/16246, PCT/US/2004/016246, PCT/US/2004/16246, PCT/US/4/016246, PCT/US/4/16246, PCT/US2004/016246, PCT/US2004/16246, PCT/US2004016246, PCT/US200416246, PCT/US4/016246, PCT/US4/16246, PCT/US4016246, PCT/US416246
InventoriDavid G Gorenstein, Bruce A Luxon, Norbert Herzog, Judith F Aronson, David Beasley, Allan Barret, Robert E Shope, Xian Bin Yang
CandidatoUniv Texas
Esporta citazioneBiBTeX, EndNote, RefMan
Link esterni:  Espacenet, Registro dei brevetti europei
Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors
EP 1667729 A4 (testo da WO2005018537A2) 
Estratto  
The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the innune response of a host animal, transcription factors such as IL-6, NF-kB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
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Citazioni di brevetti
Brevetto citato Data di registrazione Data di pubblicazione Candidato Titolo
WO2004026260A2 *17 set 20031 apr 2004Archemix Corp.Prophylactic and therapeutic hiv aptamers
WO2005003291A2 *14 ott 200313 gen 2005Board Of Regents Of The University Of Texas SystemBead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
WO2005032455A2 *20 mag 200414 apr 2005Board Of RegentsCombinatorially selected phosphorodithioate aptamer targeting ap-1
WO2005037053A2 *20 mag 200428 apr 2005Board Of Regents - The University Of Texas SystemHigh throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens
Citazioni diverse da brevetti
Riferimento
1 *KING DAVID J ET AL: "COMBINATORIAL SELECTION AND BINDING OF PHOSPHOROTHIOATE APTAMERS TARGETING HUMAN NF-KAPPA B RELA(P65) AND P50", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 41, no. 30, 30 July 2002 (2002-07-30), pages 9696 - 9706, XP009084286, ISSN: 0006-2960
Classificazioni
Classificazione internazionaleA61K, A61K48/00, C12N15/113, C12N15/115, C12N15/11
Classificazione cooperativaC12N2310/315, C12N2310/51, C12N2330/31, C12N15/111, A61K2039/55561, C12N2310/13, C12N2320/11, C12N15/113, C12N2310/16, C12N15/115, C12N2760/12211
Classificazione EuropeaC12N15/11M, C12N15/113, C12N15/115
Eventi legali
DataCodiceEventoDescrizione
14 giu 200617PRequest for examination filed
Effective date: 20051220
14 giu 2006AKDesignated contracting states:
Kind code of ref document: A2
Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
30 ago 2006DAXRequest for extension of the european patent (to any country) deleted
1 ago 2007RIC1Classification (correction)
Ipc: C12N 15/11 20060101AFI20070626BHEP
17 ott 2007A4Despatch of supplementary search report
Effective date: 20070917
4 mar 200917QFirst examination report
Effective date: 20090130
2 dic 200918DDeemed to be withdrawn
Effective date: 20090610