Cell Lineage and Embryo Patterning

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Front Cover ; Cell Lineage and Embryo Patterning; Copyright Page; Contents; Contributors; Preface; Part I: Specifications of the Cell Lineages; Chapter 1. Determinants of Cell and Positional Fate in Ascidian Embryos; I. Introduction; II. The Ascidian System; III. Determinants; IV. Evolution of Determinants; V. Identification of Determinants; VI. Concluding Remarks; References; Chapter 2. RNA Localization and Germ Cell Determination in Xenopus; I. Introduction; II. Origin and Development of Oocyte Polarity; III. Pathways of RNA Localization; IV. Role of Cytoskeleton and ER in RNA Localization. V. The Role of Cis-Acting Elements and Trans-Acting Factors in RNA LocalizationVI. Specification of Germ Line; VII. Conclusions and Future Directions; References; Chapter 3. Asymmetric Germ Cell Division and Oocyte Determination during Drosophila Oogenesis; I. Introduction; II. Self-Renewing Asymmetric Division of Germline Stem Cells as a Continuous Source of Germ Cells for Oogenesis ; III. Germline Cyst Formation via Asymmetric Cell Divisions; IV. Oocyte Determination; V. Oocyte Translocation and the Establishment of the Anterior-Posterior Axis of the Future Embryo. VI. A Comparative Analysis of Early Oogenesis and Early SpematogenesisVII. Concluding Remarks; References; Chapter 4. The Germline in C. elegans: Origins, Proliferation, and Silencing; I. Introduction; II. Formation of the Germ Lineage: Establishment of Embryonic Polarity and Segregation of Germline Factors; III. Specification of Germ Cell Fate: Function of P Granules and Associated Factors; IV. Proliferation and the Decision to Initiate Meiotic Development; V. Silencing in the Germline; VI. Concluding Remarks; References; Chapter 5. Assembly of the Drosophila Germ Plasm; I. Introduction. II. Molecular Features of the Drosophila Germ PlasmIII. Genetic and Molecular Data on the Assembly and Function of the Germ Plasm; IV. Unanswered Questions; References; Chapter 6. Early Events in Mammalian Germ Line; I. Introduction; II. Mammalian Germ Cells; III. Control of PGC Behavior; IV. Interaction of PGCs with the Environment; V. Stem Cells; VI. Conclusion; References; Part II: Patterning of the Embryo; Chapter 7. The Initial Phase of Embryonic Patterning in Mammals; I. Introduction; II. Sensitivity of Fetal Development to Conditions to which the Early Conceptus Is Exposed. III. Polarity and the Establishment of Axes of the ConceptusIV. Significance of Bilateral Symmetry of the Early Conceptus; V. Gene Expression and Molecular Asymmetries before Gastrulation; VI. When Is the Fetal A-P Axis Specified?; VII. How Compelling Is the Case against Dependence of Early Patterning on Information in the Zygote ; VIII. Concluding Remarks; References; Chapter 8. Cadherin and Catenins, Wnts and Soxs: Embryonic Patterning in Xenopus; I. Introduction; II. The Cadherin Superfamily and Cell; III. Wnts, Catenins, and the Regulation of Gene Expression